Personally, I think we should keep a solid head on our shoulders in such a scenario. No QB taken? Are you serious, we just "theoretically" got bumped into the #1 spot. By NOT taking a QB, SF has allowed Miami's #2 pick to have the same worth as #1. Thus, we now have HUGE negotiating power. Think of the teams who would suddenly be interested in wanting to trade JUST to have their CHOICE of Rogers or Smith.
I think you now have teams such as Arizona, Cleveland, Tampa Bay and Detroit seriously reconsidering their game plan. Suddenly, trading down is not just a reality, but also a very rewarding option. Not too mention the reshuffling of all draft boards it would create in the Top 10. Teams would be scrambling for positioning.
I personally believe the best suitor for our #2 is Cleveland. If Rogers or Smith is not taken with #1 AND it's also NOT traded to another team, Cleveland would love to have the opportunity to CHOOSE which QB they want.
I've also felt, if we could manage a trade with Cleveland, we would gain a pick while only losing one spot. Then, we could fall a little further in the Top 10 and gain another pick or two along the way. Meanwhile, we still position ourselves to get the player we want at a more suitable picking position for that player.
But, with all this speculation, we have to remember SF NEEDS a QB. There are NO FA QBs left and THIS is their only shot this year at a franchise QB. It's simply not gonna happen.