I think it's possible and if the player has the right value I think most would be on board with it despite the lack of glamour associated with it.
We all know we need a LG desperately, we all know the OL has been incomplete since......We've spent a lot of resources on OT and C with the 3 first rounder's and clearly tried to address the issue with a couple of third rounder's. With the talent we have on offense now is the time to make the OL as strong as possible.
I think the main problem with taking a guard in the first is that 1. Why not trade down to do it? Or conversely, why not just trade up with our second rounder to do it. There isn't as big a separation, usually, with the top guard and say the 4th best OG. Where as with DE or CB, that bridge is much wider typically.