Moving our lbs around amounts to moving chairs around on the Titantic
Disagree, if Misi can continue to be as good against the run as he has been, there will be a dramatic difference in how the LBs perform.
Even with Misi huge size, Misi can run very well sideline to sideline for a big man, and because he is so big, and strong, he will handle blockers far better then Ellerbe ever did, and Ellerbe will do much better on the outside then he did at Middle LB.
All LB positions are not created equal, trying to put a square peg in a round hole would probably get you the same results then having an athletic, but now so powerful LB try to hold the middle.
The middle LB has to be powerful at the point of attack, instinctive, and able to be the QB of the defense, Ellerbe was not that, Misi just might be, at the very least, he can be powerful and instinctive, if he can be a leader in the middle, the LB position will make a drastic improvement.
Edit: By the way, as for Wheeler, I don't know how long he will continue to start, because I have little confidence with him.