Personally, I would take a great OT, then a great pass rusher, then a great WR in that order. They are all premium positions at areas of need. Unfortunately, I don't expect that we'll get our pick of those three positions. But I wouldn't push need above taking a great player. For example, I wouldn't take a lesser OT (or a poor fit, he'd be a lesser OT for us) over a great pass rusher.
So looking at the board and trying to guess at what other teams will take at what may be available, my short list would go something like this:
Over the moon
Fautanu: I'd say 25% chance he makes it to 21, but I'd run the card up if he did.
Latu: I'd say maybe a 75% chance he makes it to 21, but another guy I see a potential perennial pro bowl player.
Happy
Barton: 75% chance to make it to 21. Another guy with perennial pro bowl potential at multiple positions.
Satisfied we made a good pick
JC Latham: 75% chance to make it to 21. Pro bowl T potential, but probably would redshirt and not play G in the interim.
Murphy: 25%-50% chance. A less premium position, but a great player.
Newton: 25%-50% chance. A less premium position, but a great player.
I wouldn't complain about any of those 6, but there's a clear 3 tiers to my level of excitement.
I'm not as high on Verse, Thomas or Mims, which are the the other ones I hear mentioned here often.
Of the WRs, I see almost zero chance of any of the top 3 making it to 21. I'm not a fan of Brian Thomas and hope he gets picked by somebody like Buffalo trading up ahead of us. My #4 WR is Legette, but I'd rather trade down (which I see as unlikely unless some team covets a QB at our spot), and get him later or pick one of my top 5 and add a WR like Pearsall or Wilson lower.