I think when you consider that Ronnie has had only 3 practices, and everyone else on the field (minus Hines ward, but he has had 5 years NFL experience) has had 3 weeks of practice and 2 preseason games underneathe thier belt, it would be a huge mistake to play him in this game.
Yes injuries are a part of football but you definetly have to temper those risks, and all of Pitt's defensive players will be far more in regular season game condition than ronnie who again has has just 3 practices, of which there has been very little contact.
Ronnie held out, and now he is behind the curve and that may initally be a scarifice to the team. However, this does not mean that we should risk his health prematurely. There is plenty of time to get him more game ready.