Well from the Saints side of it......Brees isn't playing, Reggie Bush suffered a minor injury last week so he might not go, Deuce McAllister is still recuperating from his knee surgery so he probably won't play, Marques Colston has some sore ribs so he probably won't play. Pretty much all your going to see is Mark Brunell, some of the starters on the OL, the third and fourth WRs, AND maybe the first game action by Jeremy Shockey in a Saints jersey (so far he's practiced but hasn't played in the preseason) maybe if Payton doesn't pull him at the last minute like he did last week.
On D the Saints have suffered some injuries at DT so don't expect to see our rookie Sederick Ellis or many of the Saints starters for more than a series or two. Your QB will probably be seeing a lot of "Mr. Automatic First Down" Jason David. Don't read too much into having passing success when David's on the field. He is in serious danger of not making the roster as depth. The starters at CB will be Mike McKenzie and Tracy Porter but they probably won't play much.
Good luck tonight and here's to no injuries........