question

[Negmaron]

For all of the x's and o's guys... what is the best possible way to defend pick plays?

 

[EvilDylan]

run through that receiver

 

[Fins_of_Fury]

This article is pretty informative:

http://mmqb.si.com/2014/01/15/new-england-patriots-denver-broncos-afc-championship-game-pick-plays

Defensive techniques used to combat the rubs and picks vary from team to team, and down to down. Some teams get even closer and more physical with the receiver so he can’t freely pick off a teammate. On some downs you’ll see defenders switch the players they’re covering.

 

[J. David Wannyheimer]

Don't schedule New England or Denver.

 

[FinfanInBuffalo]

Pay the refs to properly call the penalties

 

[Bumpus]

run through that receiver

This. (Then step on his nuts as you run over top of him - he won't pick you again.)