It's not the miss on Harris that's concerning. You can forgive a miss here and there. Misses are going to happen. It's the logic behind making Charles Harris your selection at #22 overall that is concerning.
You can forgive a miss on a guy with tremendous upside that they swing for the fences on that just doesn't pan out. Or a guy with no major weaknesses who is a great football player that has his career derailed by unlucky injuries. Those types of things you can understand.
I will never understand the logic behind the Charles Harris pick. Nothing in his entire body of work at Missouri, nor his pre-draft evaluation suggests that he should be valued where Miami took him. He tested poorly, liability as a run defender was well known to any evaluator, and his production wasn't there. They passed up guys who quite clearly should've had a higher grade like T.J. Watt and Tre'Davious White to select this guy. Based on what exactly?
To me, it's concerning. It points to a flaw in your process somewhere.