What's more important to you for the coming draft:
Someone who can start immediately or a player with greater long term upside but short term problems. For the sake of the debate, lets say the latter doesn't fully develop until the 2018 season.
At 13, you should be able to get both.
After that, I think it depends upon the position/needs you're filling. If you don't have two starting OG's, and you can an immediate starter at 42, that probably makes more sense for the team that using the pick on a high-upside guy that will take a while to develop. But if you're looking at a rare Edge talent that fell because he's raw (Danielle Hunter), the value may be too good to pass up. Unless Ogbah falls to 42, that won't be an issue in this draft.
After the 2nd RD, though, almost all the players have enough holes in their games to make counting on them as starters a mistake. In the first two rounds, I'd look for players I could count on to start, with the most upside possible, but 3-7, unless a starting caliber OG (for example) falls, I'm drafting for upside within the system. Obviously, you want the best/most refined players, but if you're getting a super refined guy in RD 4, there's a good chance he doesn't have the physical tools to be anything more than an average player in the NFL. There are always exceptions. The NFL misses guys each year, but since we're discussing rules of practice, you don't do yourself any favors by filling your roster with average 3rd and 4th-year starters.
High-upside to me isn't going to be the same thing as high upside to Tom, Dick, or Harry. If we were to get too specific, that would muddle the conversation pretty quickly.