You've gotta go QB in round 1 unless we get to the AFC championship game.
Here's why: Our defense is STACKED. Yeah, we could use a safety, but unless the next Ronnie Lott or Ed Reed is sitting there, this can wait until Round 2 or 3, and we have a lot of young safeties on the roster as is and any one of them could step up.
On offense, we have Long, Carey, and Pouncey as fixed starters. We need a RT and we need a LG. You don't pick RT's in round 1 (typically you see guys picked as a LT in that round that end up making the switch to RT because they couldn't cut it at LT). And considering we just spend last years first on an interior OL, it would be silly to do that again.
At WR we have Marshall and Bess, and while a better #2 option than Hartline would be nice, it's not essential at this point. Marshall is a #1 WR and you don't draft a guy to be a #2 in Round 1.
at RB we just spend a high pick on Daniel Thomas and traded for Reggie Bush. Running backs are notorious for being found in later rounds/off the street/UDFA's. It's not a big enough need considering what we've recently spent on it.
TE is the next biggest need, but there were TE's on the market this year that we didn't go after, which makes you think that they believe Clay and Fasano have enough to hold down the position. Also, TE's typically do not get picked until the end of round 1, and those that have been picked early of late (Marcedes Lewis, Vernon Davis and Kellen Winslow come to mind) didn't really make an immediate impact.
That leaves QB, and in a VERY good QB class, it's the right time to make a splash. I would put our situation very similar to the Chargers with Drew Brees when they drafted Eli Manning..er..., I mean Philip Rivers. Brees hadn't done much at that point, and the team was mediocre, so they went out and drafted Rivers. Brees went 8-8 in 2002 and was benched in 2003 for Doug Flutie before the Chargers drafted Rivers, it wasn't until Rivers was in the fold that Brees became the QB he is today.
This class has a bunch of guys that could be potential franchise QB's, Andrew Luck, Landry Jones, Matt Barkley, and Nick Foles immediately come to mind. And as always there will be guys who are rated as 3rd and 4th round prospects now that will shine and improve their stock to possible 1st round status. There is no excuse not to draft a QB in round 1 in 2012.