My bad I watched a different video that had 2010 mixed in, I see your point when Koa Misi played your right he did face LT's. You have to admit even the video message stated due to Koa Misi being handled by the LT he made teams double and sometimes triple team (chip block) Cameron Wake. Its not like Cameron Wake was 1 on 1 with the RT, so there isn't much of an advantage that you speak of outside of him simply being a beast.
Do you honestly think if he (Wake) is 1 on 1 with any Tackle 7 - 10 times he wouldn't abuse that Tackle no matter which side they lined up on? Rushing from the QB's blind side is an advantage IMO, not getting doubled teamed.
In a 4-3 defense Cameron will be the RDE IMO facing up against the LT, this for most teams is the weak side run.
Running behind you LT with no TE next to him means your bringing a lead blocker to fill that void in power run plays. If they line up a TE next to the LT the strongside linebacker would adjust over to that side to anticipate a strong side run.