I just got finished watching the Bills/Pats game. The Bills actually outplayed the Pats imo, but some dumb penalties, dropped INTs, and turnovers doomed them. That being said, Fred Jackson was a big part of their offense. He provides all the tough running up the middle. Without him, I dont think Spiller will be as effective. Spiller is a better version of Bush.
Their TE Chandler will likely do some damage against us, and I could see Stevie showing up Sean Smith. Overall though, I think if we can get pressure on Fitzpatrick (he is easily sacked from the looks of the Pats game), this game should be pretty close...