Read a book once on the 'lonesome polecat' offense, the forerunner to run and shoot. It was basically done by a high school team because they had nobody able to play offensive line.....they put two lineman over the ball and spread the rest of the team to either side of the field, getting enough on the LOS to make it legal.
I think the two offensive lineman they put over the ball have to better than the five we start today.