In the NFL nothing is impossible. Teams do things that seem like a crazy idea at the time, but then it works out in the end.
Take for example we could package two defensive stars (not going to say who, just use your imagination) and offer them, plus our first round pick to a top three team. They still get a first rounder, AND set their defense up for a good long run.
We get Manning, plus still have our entire draft to fill in the defense we lost. Remember now, both our starting CB's were 2nd rounders, Jason a third, Zach a fifth...hell O gun was undrafted if I remember correctly!
We then retool the O Line using players we already have, and add just one or two soild vets via FA.
Ricky Williams, Eli Manning, a re-tooled O line...patch in the defense, and we have a solid future.
So in theory, it is very possible to grab Eli...just have to make it work.
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P.S. Don't forget though, Marino was a late first round pick...so just because Eli is supposed to be good, maybe Spielman and Co have a better idea.