I don't think Manning = Brady/Belicheck in terms of completely patching up problem areas in a short-time span, and completely fooling opponents. The Rams were not the first time this season that Denver played poorly.
If we can pressure Peyton and keep his options limited with good coverage (Jones, Grimes, Finnegan, Jordan, Delmas all doing their thing giving receivers fits) then I think this game is very winnable. Just gotta make sure to clamp down on the checkdowns and shovel passes too down the middle.
Also hope our line is good enough not to fall for his hard counts, or show blitz too early. Discipline will be necessary. This is a game that will test not only how talented our D is, but how smart they are.
And the O needs to SCORE!