On the final day of minicamp (2016), Howard suffered a
knee injury and was placed on the physically unable to perform list after it was discovered he would require surgery.
On October 6, 2016, Howard suffered
another knee injury during practice. The meniscus injury required surgery and he missed the next nine games.
In Week 13 of the 2018 season, Howard
injured his knee after intercepting Bills' quarterback
Josh Allen for the second time that afternoon. He went on to miss the final four games of the regular season.
(2019) Howard was forced to miss the next three games due to a
knee injury.
He made his return in week 8 against the
Pittsburgh Steelers. In the game, Howard recorded an interception off a pass from
Mason Rudolph that was intended for
JuJu Smith-Schuster before
reinjuring his knee.